VThunter
a database for single-cell screening of virus target cells in animal kingdom
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Civet

Scientific Name: Paguma larvata

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Carnivora-> Feliformia

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Lymphocytic choriomeningitis mammarenavirus

Family: Arenaviridae

Receptor: CLEC4G

Receptor CLEC4G information

Summary: This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020] [NCBI]  [Proteinatlas]

Data Source

Data set information

Project Date Technology Tissue Condition Cell PMID/DOI
Vthunter_0007 2021.04 10X Genomics Frontal Normal 6593 Link
Vthunter_0008 2021.04 10X Genomics Kidney Normal 1930 Link
Vthunter_0009 2021.04 10X Genomics Liver Normal 34029 Link
Featureplot of receptors

Featureplot of receptors

mRNA expression of CLEC4G in human tissues   [NCBI]

Expression: Biased expression in liver (RPKM 17.2), lymph node (RPKM 6.5) and 4 other tissues

Protein expression of CLEC4G in human tissues   [Proteinatlas]